In comparison with atorvastatin, rosuvastatin is related to a better danger of blood within the urine and renal failure requiring alternative remedy.
Larger doses of rosuvastatin might have lasting and damaging results on the kidneys, in response to a examine printed in JASN based mostly on the affected person’s well being document.1
Rosuvastatin is within the statin class of medicines proven to decrease excessive ldl cholesterol.1 Reducing ldl cholesterol within the blood can forestall coronary heart assaults, strokes, and might even cut back the danger of dying from coronary heart illness by 25%-35%.2
The kidneys work to stability water and minerals within the blood and take away waste from the blood.3 Injury to those organs creates dysbiosis because of the accumulation of waste and fluid within the physique.3 Widespread signs of injury embrace shortness of breath, swollen ankles, nausea, weak point, and poor sleep, however an excessive amount of harm can result in life-threatening kidney failure.3
Different indicators of kidney harm embrace hematuria and proteinuria, which had been noticed when rosuvastatin was authorized by the FDA.1 For the examine, Jung-Im Shin, MD, PhD, of the Johns Hopkins Bloomberg Faculty of Public Well being, and colleagues examined digital well being document knowledge from 2011-2019. Shin in contrast 152,101 new customers of rosuvastatin with 795,799 new customers of the same statin, atorvastatin.1
Researchers discovered that 2.9% of rosuvastatin sufferers had hematuria and 1.0% had proteinuria throughout a median follow-up of three.1 years.1 Rosuvastatin was related to a 17% greater danger of proteinuria than atorvastatin, together with an 8% greater danger of hematuria and a 15% danger of renal failure, requiring dialysis alternative remedy or transplantation.1
Researchers additionally discovered that physicians have exceeded the really helpful dose of rosuvastatin, as decided by the FDA, to sufferers with superior kidney illness.1 Researchers discovered that the danger of sufferers experiencing hematuria and proteinuria elevated because the dose elevated, and based mostly on the examine, 44% of sufferers took greater doses than authorized.1
“We noticed a better danger of hematuria, proteinuria, and renal failure with rosuvastatin use and related cardiovascular advantages between the rosuvastatin and atorvastatin teams,” Shin mentioned.1 “As a result of rosuvastatin could cause proteinuria and hematuria, particularly with excessive doses, high-dose rosuvastatin will not be definitely worth the danger—nonetheless small—particularly for sufferers with superior kidney illness.”1